Histopathological Characterization and Expression of Vitamin D Receptor in the Prostate of Healthy Dogs and Dogs with Prostatic Carcinoma

Vitamin D Receptor (VDR) expression is implicated in human Prostatic Carcinoma (PC), but its role canine PC unclear. To investigate how VDR affected by age and castration healthy dogs it changes with PC, we evaluated prostates from 8-month-old (n = 5) or 6-year-old 8) intact males, 1-8-year-old castrated males 4) 8-15-year-old 7) performing histopathology, immunohistochemistry, ELISA. The results showed that prostate increased an age-dependent manner decreased after compared at 6 years of age. Castrated differed according to the pattern tumor proliferation. findings suggest prostatic may be a useful prognostic marker therapeutic target for PC.